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2.
Br Heart J ; 69(3): 233-6, 1993 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-8461221

RESUMEN

OBJECTIVE: To evaluate whether circulating endothelin, a peptide that is thought to play a part in mediating vascular tone, might be high in pulmonary hypertensive congenital heart disease. DESIGN: A prospective study with a radioimmunoassay technique to estimate urinary and plasma endothelin concentrations. SETTING: A supraregional referral centre for patients with congenital heart disease. PATIENTS: The 12 hour urinary endothelin concentration in young children with an increased pulmonary blood flow (n = 24, median age eight months) were compared with those in children with right ventricular outflow tract obstruction (n = 14, median age 1.5 years) and with those in healthy controls (n = 16, median age 1.8 years). The concentrations were also measured in adolescents with irreversible pulmonary vascular disease (n = 17, median age 18 years) and compared with those in controls of similar age (n = 19, median age 18.5 years). Also the plasma concentrations in the left atrium and pulmonary artery were measured in young children with either high (n = 11, median age 10.8 months) or low (n = 5, median age 1.0 year) pulmonary blood flow, in the peripheral arterial and venous blood of young children with either high (n = 13, median age 10.8 months) or low (n = 6 median age 1.9 years) pulmonary blood flow, and in the peripheral venous blood of seven healthy young children (median age 1.7 years). RESULTS: The urinary excretion of endothelin was similar in young children of a similar age, whether they had high, low, or normal pulmonary blood flow. Also, urinary endothelin excretion in older patients with irreversible pulmonary vascular disease was similar to that in normal subjects of similar age. Urinary endothelin excretion in normal young children, however, was significantly greater than that in normal older subjects (p = 0.0001). There was no transpulmonary or arteriovenous difference detected in either children with high or low pulmonary blood flow, and plasma concentrations sampled from the left atrium, pulmonary artery, and systemic artery and vein were similar in both groups. CONCLUSION: There was no evidence to implicate circulating endothelin in the pathogenesis of pulmonary vascular disease.


Asunto(s)
Endotelinas/sangre , Cardiopatías Congénitas/sangre , Adolescente , Endotelina-1 , Endotelinas/orina , Femenino , Cardiopatías Congénitas/orina , Humanos , Lactante , Masculino , Estudios Prospectivos , Precursores de Proteínas/sangre , Precursores de Proteínas/orina , Enfermedad Cardiopulmonar/sangre , Enfermedad Cardiopulmonar/orina , Radioinmunoensayo
5.
Pol Med Sci Hist Bull (1973) ; 15(4): 425-30, 1975.
Artículo en Inglés | MEDLINE | ID: mdl-1223829

RESUMEN

The purpose of this work was to study the excretion of free adrenaline (A), noradrenaline (NA) and vanilylmandelic acid (VMA) in 24-hour urine in patients with chronic circulatory failure. The investigations were carried out in a group of 152 patients (61 women and 91 men) with rheumatic valvular heart disease (61 cases), chronic cor pulmonale syndrome (23), atherosclerotic myocardial degeneration (68). A and NA urinary excretion was normal in cases with grades 1 and 2 of hemodynamic disturbances. In cases with grades 3 and 4 the excretion of catecholamines was significantly raised, especially that of NA. With regression of circulatory failure the excretion of catecholamines decreased even to normal level. Increased VMA excretion was observed only in cases with grade 4 hemodynamic disturbances. The only factor influencing the function of the adrenergic system and excretion of catecholamines was the degree of circulatory failure. Stimulation of adrenergic system in chronic circulatory failure counteracts the effects of hemodynamic disturbances caused by circulatory failure.


Asunto(s)
Epinefrina/orina , Cardiopatías/orina , Norepinefrina/orina , Ácido Vanilmandélico/orina , Adulto , Anciano , Arteriosclerosis/orina , Circulación Sanguínea , Femenino , Cardiopatías/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Enfermedad Cardiopulmonar/orina , Cardiopatía Reumática/orina
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